98. Detective work in Parkinson's Disease

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Discovery Matters

109 episodes

1 week ago

A collection of stories and insights on matters of discovery that advance life sciences. Brought to you by the curious people at Cytiva.

Life Sciences

Science

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A collection of stories and insights on matters of discovery that advance life sciences. Brought to you by the curious people at Cytiva.

Life Sciences

Science

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98. Detective work in Parkinson's Disease

Discovery Matters

25 minutes 36 seconds

10 months ago

98. Detective work in Parkinson's Disease

In this episode of Discovery Matters we delve into groundbreaking advancements in Parkinson’s disease research. Dodi and Conor transport us to the frontier of medical innovation, exploring the latest discoveries and techniques that hold promise for early diagnosis and treatment of Parkinson’s disease.

Show notes

• Decet, Marianna et al. ‘A candidate loss-of-function variant in SGIP1 causes synaptic dysfunction and recessive parkinsonism’, Cell Reports Medicine, Volume 5, Issue 10.

• Hällqvist, J., Bartl, M., Dakna, M. et al. ‘Plasma proteomics identify biomarkers predicting Parkinson’s disease up to 7 years before symptom onset’. Nat Commun 15, 4759 (2024).

• Roald Dahl's Marvellous Children's Charity

Keywords: non-invasive procedure, early diagnosis, synaptic homeostasis, Parkinsonism, biomarkers, machine learning, REM sleep disorder, inflammatory pathways, dopaminergic cells, predictive diagnostics, early intervention.