This research introduces a novel biosensing strategy using surface-enhanced Raman spectroscopy (SERS) for the multiplexed detection of serum cardiac markers, crucial for diagnosing acute myocardial infarction. The method employs a specially designed plasmonic metasurface with enhanced electric and magnetic fields to improve SERS signal consistency. Furthermore, it utilises nanomechanical perturbations to transduce signals as frequency shifts, overcoming limitations associated with SERS intensity fluctuations. By integrating this metasurface with 3D-printed microfluidics, the study demonstrates a single-antibody-based assay capable of simultaneously and specifically detecting multiple cardiac biomarkers in serum samples, presenting a significant advancement in quantitative optical diagnostics.
Research paper:
P. Zheng, L. Wu, P. Raj, J. H. Kim, S. K. Paidi, S. Semancik, I. Barman, Multiplexed SERS Detection of Serum Cardiac Markers Using Plasmonic Metasurfaces. Adv. Sci. 2024, 11, 2405910.
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