This research article investigates how long-term memories persist despite the turnover of brain molecules. The study reveals that a protein called KIBRA physically interacts with the enzyme PKMζ at synapses activated during learning. This KIBRA-PKMζ complex acts as a stable anchor, maintaining the synaptic changes underlying memory storage. Blocking this interaction with specific inhibitors disrupts established long-term potentiation and erases both recent and remote memories in animal models, highlighting the crucial role of this continuous molecular coupling in memory maintenance.
Review paper:
Tsokas P, Hsieh C, Flores-Obando RE, Bernabo M, Tcherepanov A, Hernández AI, Thomas C, Bergold PJ, Cottrell JE, Kremerskothen J, Shouval HZ, Nader K, Fenton AA, Sacktor TC. KIBRA anchoring the action of PKMζ maintains the persistence of memory. Sci Adv. 2024 Jun 28;10(26):eadl0030.
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