This study investigates the association between frailty and cardiovascular disease (CVD) in three large, prospective cohorts from China, the UK, and the USA. The researchers assessed participants' frailty status using the Rockwood frailty index, taking into account changes in frailty over time. The findings show that frailty progression, particularly from robust to pre-frail or frail, significantly increases the risk of incident CVD, while frailty recovery, specifically from frail to robust or pre frail, decreases CVD risk. This research suggests that frailty is a modifiable risk factor for CVD and highlights the importance of early intervention to prevent frailty progression and promote recovery from frailty.
Research paper:
He D, Wang Z, Li J, Yu K, He Y, He X, Liu Y, Li Y, Fu R, Zhou D, Zhu Y. Changes in frailty and incident cardiovascular disease in three prospective cohorts. Eur Heart J. 2024 Mar 27;45(12):1058-1068. Erratum in: Eur Heart J. 2024 May 21;45(19):1768.
Click here to read the review article
Voiced by NotebookLM
