Join Drew and Dr. Dwayne Jackson for an in-depth exploration of why exogenous ketones are experiencing a renaissance - and it has nothing to do with fat loss. Discover cutting-edge mitochondrial peptides, the truth about NAD injections, and how to build the ultimate energy optimization stack without breaking the bank.
KEY TAKEAWAYS
EPISODE BREAKDOWN
The Ketone Renaissance Dr. Jackson explains why ketones disappeared from the market and what's driving their comeback. The key insight: they're not for fat loss when taken exogenously, but rather provide alternative brain fuel and ATP production, especially during carbohydrate restriction.
Bedtime Ketones: The Sleep Game Changer Discover the emerging research on ketones improving sleep latency, REM sleep, and recovery. Drew shares his personal experience tracking HRV improvements with nightly ketone consumption.
Dual Fueling for Athletes Learn how endurance athletes are combining glucose and exogenous ketones for sustained energy without GI distress. Dr. Jackson breaks down the physiology of energy system switching during prolonged exercise.
Mitochondrial Peptides Deep Dive SS31 (Elamipretide) emerges as the most researched option for mitochondrial health, working by stabilizing electron transport chain complexes and reducing oxidative stress. Compare this to newer options like SLU-PP-332.
Methylene Blue Protocols Critical dosing information for methylene blue (0.25-1mg per kg bodyweight) and why higher doses can cause oxidative damage. Plus the serious drug interactions with SSRIs that could cause serotonin syndrome.
Budget-Friendly Alternatives CoQ10 (200-400mg ubiquinol), NAD precursors (NR 300mg, NMN 500mg), and PQQ (20-40mg) provide mitochondrial benefits at a fraction of peptide costs.
The Foundation First Philosophy Both experts emphasize that no supplement stack can overcome poor lifestyle habits. These advanced protocols only shine when training, diet, recovery, and stress management are already optimized.
DOSING PROTOCOLS
SS31: 40-80mg subcutaneous, morning dosing during training phases Methylene Blue: 0.5-1mg oral daily (never exceed 4mg total) CoQ10: 200-400mg ubiquinol form NAD Precursors: NR 300mg or NMN 500mg daily PQQ: 20-40mg daily Ketones: Product-dependent, aim for 1.5-2.0 millimolar blood levels
SAFETY WARNINGS