The Pod of Asclepius is a healthcare technology podcast for the technical crowd.
No fluff, no sales pitches, just important health tech ideas (described well!) to help everyone keep learning and becoming more of an expert in the field.
Our guests are top researchers (from academia and industry), entrepreneurs, and regulatory experts. They will talk about cool technology, from data science to engineering, but also share insights on practical concerns of bridging the gap between technical innovation and a clinical solution.
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The Pod of Asclepius is a healthcare technology podcast for the technical crowd.
No fluff, no sales pitches, just important health tech ideas (described well!) to help everyone keep learning and becoming more of an expert in the field.
Our guests are top researchers (from academia and industry), entrepreneurs, and regulatory experts. They will talk about cool technology, from data science to engineering, but also share insights on practical concerns of bridging the gap between technical innovation and a clinical solution.
Philosophy of Data Science | Jingyi Jessica Li | Advancing Statistical Genomics
Data & Science with Glen Wright Colopy
1 hour 22 minutes 42 seconds
3 years ago
Philosophy of Data Science | Jingyi Jessica Li | Advancing Statistical Genomics
Jingyi Jessica Li | Advancing Statistical Genomics
Watch it on…. YouTube Podbean
Jingyi Jessica Li (UCLA) describes common statistical pitfalls in genomic data analysis & the statistical reasoning required to correct these mistakes.
Common themes throughout include:
Hypothesis-driven science & critical scientific reasoning over data
p-values and non-sensical null hypotheses/distributions
the value of appearing statistically rigorous
researchers cutting intellectual corners & digging themselves into local minima
Episode Topics
0:00 A major advancement in genomic data leads to new statistical techniques
2:15 Hypothesis-driven science & hypothesis-free data analysis
2:55 A ChIP Seq Example
8:00 Misformulation of sampling variability
16:55 A false analogy: the permutation test
19:03 Losing my p-value religion: the value of statistical packaging
24:30 The Clipper Framework for false discovery rate control
31:50 Non-parametric developments
37:55 Inferred covariates
46:00 PseudotimeDE: inferences of differential gene expression along cell pseudotime
47:10 Selective inference
49:25 What biological/physiological data will be incorporated in the future?
52:30 Statistics, computer science, data science, ML, biology
57:05 Machine learning and prediction
1:01:30 Sophisticated models vs sophisticated research
1:07:45 Peer review in science
1:13:05 Hypothesis-driven science vs cutting intellectual corners
1:18:12 What topic should the statistics community debate?
Data & Science with Glen Wright Colopy
The Pod of Asclepius is a healthcare technology podcast for the technical crowd.
No fluff, no sales pitches, just important health tech ideas (described well!) to help everyone keep learning and becoming more of an expert in the field.
Our guests are top researchers (from academia and industry), entrepreneurs, and regulatory experts. They will talk about cool technology, from data science to engineering, but also share insights on practical concerns of bridging the gap between technical innovation and a clinical solution.
