In this episode of Fast Physiology on the Critical Oxygen Podcast, Dave Schell and I discuss fatigue. We explore the physiological mechanisms, the role of ATP in muscle contraction, and how specific training can enhance fatigue resistance. We discuss the protective nature of fatigue (i.e. why we fatigue), the importance of understanding metabolic acidosis, and the need for tailored training to prepare for endurance events. The conversation emphasizes the multifactorial aspects of fatigue and the significance of maintaining ATP levels during exercise. TAKEAWAYS - Fatigue is a protective mechanism to prevent catastrophic muscle damage. - Mitochondria help buffer hydrogen ions during exercise. - Factors like heat, and metabolic acidosis contribute to fatigue through different mechanisms. If you have a question or topic you want us to address, leave a comment! Follow Phil on Instagram - https://www.instagram.com/criticalo2 Follow Dave on Instagram - https://www.instagram.com/kaizenendurance/ OR YouTube - https://www.youtube.com/@UCT5Cy95BiLIDQh4KS5bohhQ Interested in Gravel or Mountain Bike Coach? Head to Dave's website - https://www.kaizenendurance.coach/ Want to learn more physiology, check out my blog, and courses - https://www.criticaloxygen.com/ CHAPTERS 00:00 Understanding Fatigue: A Protective Mechanism 07:00 Physiological Mechanisms Behind Fatigue 13:07 The Role of ATP and Muscle Contraction 21:05 Training for Fatigue Resistance 25:01 Key Takeaways and Conclusion KEYWORDS fatigue, exercise physiology, ATP, muscle contraction, endurance training, metabolic acidosis, performance, fatigue resistance, physiological mechanisms, training adaptation