Our guest in this episode of the Computomics Podcast is Alain Tissier, Managing Director at the Leibniz Institute of Plant Biochemistry. He discusses his research focusing on the molecular mechanisms in plants, particularly the interaction between primary and secondary metabolism and how plants produce chemical compounds for defense and communication. Alain talks about on his work in metabolic engineering and genome editing, particularly using a novel CRISPR-based technology to introduce specific genetic changes in plants. Hear about the INNO-TOM project which uses pangenomes to breed disease-resistant and nutrient-enriched tomatoes.