IgA nephropathy (IgAN) presents with a wide range of clinical signs, making timely detection and coordinated care essential. This multidisciplinary approach to diagnosis and management can manifest in a number of ways, from clinical evaluation and laboratory testing to emerging biomarkers and evolving treatment options. Joining Dr. Gates Colbert to discuss how we can use these strategies to optimize IgAN care are Drs. Abdallah Geara and Ellie Kelepouris. Dr. Geara is an Associate Professor of Clinical Medicine, the Clinical Director of the Glomerular Diseases Program, and Director of Onconephrology at Penn Medicine in Philadelphia, and Dr. Kelepouris is a Professor of Clinical Medicine, the Vice Chief of Clinical Affairs, and the Medical Director of Outpatient Dialysis Programs at Penn Medicine.