In the second part with Prof. Satchidananda (Satchin) Panda (Regulatory Biology Laboratory at the Salk Institute for Biological Studies in La Jolla, California), we continue talking about breakthrough discoveries from past years of him and other chronobiologists. First, we discuss how the timing of medication intake could help in optimizing its effects. Then, Satchin shares his perspective on ongoing developments in the lighting industry since the discovery of the blue-light sensitive melanopsin. In both contexts, we also discuss self-limiting features of chronobiology and circadian rhythms research that may stand in the way of using chronobiological principles to achieve policy changes in clinical practice and that should ideally be overcome to collaborate better with other medical disciplines as well as the industry. Lastly, Satchin shares his simple way of measuring scientific success.
Chapters:
(00:01:14) Intro
(00:03:00) Timing medicines
(00:08:18) Self-limiting features of chronobiology
(00:15:56) Wearable technologies and chronobiology
(00:20:22) More engagement with other disciplines
(00:29:00) Daylight-mimicking electric light
(00:34:04) Funny anecdote
(00:37:45) How to measure scientific success?
(00:41:07) Satchin’s book and podcast
(00:45:09) Outro
Studies that Satchin refers to:
John Hogenesch timing of drugs paper:
“Dosing time matters”
https://doi.org/10.1126/science.aax7621
“Clocks, cancer, and chronochemotherapy”
https://doi.org/10.1126/science.abb0738
“Could a good night's sleep improve COVID-19 vaccine efficacy?”
https://doi.org/10.1016/S2213-2600(21)00126-0
“Biological rhythms in COVID-19 vaccine effectiveness in an observational cohort study of1.5 million patients”
https://doi.org/10.1172/JCI167339
Timing of pain medication intake at evening or bedtime to manage pain in the morning:
“Bedtime Single-Dose Prednisolone in Clinically Stable Rheumatoid Arthritis Patients”
https://doi.org/10.5402/2012/637204
TRF increases the robustness and numbers of genes that cycle:
“Time of feeding and the intrinsic circadian clock drive rhythms in hepatic gene expression”
https://doi.org/10.1073/pnas.0909591106
“Diurnal transcriptome landscape of a multi-tissue response to time-restricted feeding in mammals”
https://doi.org/10.1016/j.cmet.2022.12.006
CRY double knockout mice still have metabolic rhythms upon TRF:
“Time-Restricted Feeding Prevents Obesity and Metabolic Syndrome in Mice Lacking a Circadian Clock”
https://doi.org/10.1016/j.cmet.2018.08.004
“A Free-Choice High-Fat High-Sugar Diet Alters Day–Night Per2 Gene Expression in Reward-Related Brain Areas in Rats”
https://doi.org/10.3389/fendo.2018.00154
“Repeated exposures to daytime bright light increase nocturnal melatonin rise and maintain circadian phase in young subjects under fixed sleep schedule”
https://doi.org/10.1152/ajpregu.00211.2006
“Bright light exposure during the daytime affects circadian rhythms of urinary melatonin and salivary immunoglobulin A”
https://doi.org/10.3109/07420529909116864
“Positive effect of daylight exposure on nocturnal urinary melatonin excretion in the elderly: A cross‑sectional analysis of the HEIJO‑KYO study”
https://doi.org/10.1210/jc.2012-1873
Satchin’s melanopsin discovery paper:
“Melanopsin (Opn4) Requirement for Normal Light-Induced Circadian Phase Shifting”
https://doi.org/10.1126/science.1076848
The Economist article “Light therapeutics”:
https://www.economist.com/1843/2014/12/29/the-light-therapeutic?utm_campaign=shared_article
Amandine Chaix paper that TRF is both preventative and therapeutic, 5 days TRF and 2 days not:
“Time-restricted feeding is a preventative and therapeutic intervention against diverse nutritional challenges”
https://doi.org/10.1016/j.cmet.2014.11.001
Satchin’s resources:
His book: “The Circadian Code”
His podcast: “Performance around the clock” (also on Spotify)
“MyCircadianClock” app
Panda Lab homepage: https://panda.salk.edu/