The podcast "Epigenetics in Precision Medicine" is based on Blog #178 from Klaus Rudolf’s blog and explains how epigenetic editors can precisely regulate gene activity without altering the DNA sequence. In contrast to gene editing, these editors enable potentially reversible changes by modifying epigenetic markers such as DNA methylation and histone modifications. The podcast highlights the advantages over gene editing, including lower risks of off-target mutations and important ethical considerations. It also presents recent technological advances and early clinical trials of epigenetic therapies for hepatitis B and muscular dystrophy (FSHD), while discussing challenges such as targeted delivery and the durability of therapeutic effects.