Ketamine is revolutionizing mental health care, offering rapid, life-changing relief for depression, anxiety, and PTSD by targeting the brain’s glutamate system and blocking NMDA receptors—often producing results within hours. Once known solely as an anesthetic, it is now a breakthrough therapy, with the FDA’s 2019 approval of esketamine nasal spray marking a major milestone. Research suggests ketamine may even help "reset" neural pathways, supporting lasting recovery. With expert supervision and refined treatment protocols, ketamine is proving to be a safe, effective, and transformative option for those who haven’t responded to traditional therapies.