Sylke Poehling didn’t set out to lead one of the world’s most advanced gene therapy companies - but a love for drug discovery and a career built on curiosity, courage and conviction brought her there.  Now CEO of Spark Therapeutics and SVP at Roche, Sylke joins us on Careers in Discovery to share her journey from academia into Biotech, how Spark pioneered the world’s first FDA-approved directly administered gene therapy, and what it means to build the next generation of treatments - and the company culture to deliver them.  She reflects on what it takes to lead through risk and uncertainty, how to balance scientific ambition with operational focus, and why authenticity and clarity are at the heart of impactful leadership.  An inspiring conversation with a scientist-turned-CEO who’s still pushing boundaries and redefining what’s possible in genetic medicine.