Welcome to Cardiology Today – Recorded October 27, 2025. This episode summarizes 5 key cardiology studies on topics like cardiovascular outcomes and N.R.4.A.2. Key takeaway: Targeting P2Y14R Prevents Venous Thrombosis. Article Links: Article 1: Short-Term Anticoagulation versus Dual Antiplatelet Therapy for Preventing Device Thrombosis Following Left Atrial Appendage Closure: The ANDES Randomized Clinical Trial. (Circulation) Article 2: Targeting P2Y14R alleviates platelet-induced NET formation and venous thrombosis through PKA/AKAP13/RhoA axis. (European heart journal) Article 3: Role of Stress-Responsive NR4A2 in Aldosterone-Producing Cell Cluster Formation. (Hypertension (Dallas, Tex. : 1979)) Article 4: Treating Malignant Hypertension With the Low-Sodium, Low-Protein, and Low-Fat Rice Diet. (Hypertension (Dallas, Tex. : 1979)) Article 5: Estrogen Influences Human Microvascular Endothelial Function Via Sex-Specific Regulation of Sphingolipids. (JACC. Basic to translational science) Full episode page: https://podcast.explainheart.com/podcast/targeting-p2y14r-prevents-venous-thrombosis-10-27-25/ Featured Articles Article 1: Short-Term Anticoagulation versus Dual Antiplatelet Therapy for Preventing Device Thrombosis Following Left Atrial Appendage Closure: The ANDES Randomized Clinical Trial. Journal: Circulation PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41139402 Summary: The A.N.D.E.S. Randomized Clinical Trial prospectively compared antithrombotic strategies after transcatheter left atrial appendage closure for patients with non-valvular atrial fibrillation. This multicenter international study randomized patients to either anticoagulation or dual antiplatelet therapy to determine the optimal approach for preventing device-related thrombosis. The trial’s objective was to establish which treatment strategy more effectively mitigates device-related thrombosis post-procedure. This research provides crucial evidence to guide clinical practice, potentially improving patient safety and outcomes following left atrial appendage closure. Article 2: Targeting P2Y14R alleviates platelet-induced NET formation and venous thrombosis through PKA/AKAP13/RhoA axis. Journal: European heart journal PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41143464 Summary: This study investigated the role of the P2Y14 receptor, highly expressed on neutrophils, in venous thromboembolism. Researchers discovered that the P2Y14 receptor mediates neutrophil extracellular trap formation, which exacerbates thrombo-inflammatory responses and venous thromboembolism. Critically, targeting the P2Y14 receptor successfully alleviated platelet-induced neutrophil extracellular trap formation and venous thrombosis by modulating the P.K.A. / A.K.A.P.13 / R.h.o.A. axis. These findings establish the P2Y14 receptor as a promising therapeutic target for developing new strategies to combat venous thromboembolism. Article 3: Role of Stress-Responsive NR4A2 in Aldosterone-Producing Cell Cluster Formation. Journal: Hypertension (Dallas, Tex. : 1979) PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41140167 Summary: This study investigated the mechanisms driving aldosterone-producing cell cluster formation, which are frequently observed in primary aldosteronism. Researchers utilized an integrated analysis of spatial transcriptomics and single-cell ribonucleic acid sequencing on aldosterone-producing cell clusters, aldosterone-producing adenomas, and zona glomerulosa cells. The study aimed to elucidate the role of the stress-responsive N.R.4.A.2 gene in this process. Establishing a clearer understanding of these mechanisms provides a foundational basis for developing new diagnostic and therapeutic strategies for primary aldosteronism and related hypertension. Article 4: Treating Malignant Hypertension With the Low-Sodium, Low-Protein, and Low-Fat Rice Diet. Journal: Hypertension (Dallas, Tex. : 1979) PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41140152 Summary: This retrospe