Welcome to Cardiology Today – Recorded November 02, 2025. This episode summarizes 5 key cardiology studies on topics like acute coronary syndrome and A.T.T.R.-C.M.. Key takeaway: Survival Odds Slash Heart Failure Trial Bias. Article Links: Article 1: Cannabis use among young adults with acute coronary syndrome: impact on initial presentation and long-term prognosis. (Heart (British Cardiac Society)) Article 2: Left ventricular transthyretin amyloid load and apical sparing in patients with newly confirmed transthyretin amyloid cardiomyopathy. (European journal of heart failure) Article 3: Survival Odds to Minimize Risk Heterogeneity Bias in Heart Failure Trials: Application to Dapagliflozin. (Circulation. Heart failure) Article 4: Impact of the Swedish Care Coordination Act on Heart Failure Readmissions and Length of Stay. (Circulation. Heart failure) Article 5: Timing and Mode of Death Following Treatment of Neonatal Symptomatic Tetralogy of Fallot. (Journal of the American Heart Association) Full episode page: https://podcast.explainheart.com/podcast/survival-odds-slash-heart-failure-trial-bias-11-02-25/ Featured Articles Article 1: Cannabis use among young adults with acute coronary syndrome: impact on initial presentation and long-term prognosis. Journal: Heart (British Cardiac Society) PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41176318 Summary: This retrospective cohort study assessed the association between cannabis use at admission for acute coronary syndrome, or A.C.S., and long-term prognosis in young adults under 45 years old. Patients admitted between 2010 and 2025 who reported current tobacco use were classified based on urinary testing for cannabis upon admission. The research aimed to clarify the cardiovascular impact of cannabis use, which is increasing among young adults, by examining its link to long-term outcomes following an A.C.S. event. This study established a methodology to investigate the clinical implications of cannabis exposure on cardiovascular health in a high-risk population. Article 2: Left ventricular transthyretin amyloid load and apical sparing in patients with newly confirmed transthyretin amyloid cardiomyopathy. Journal: European journal of heart failure PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41168134 Summary: This study investigated the relationship between echocardiographic apical sparing, a hallmark imaging feature quantified by the R.E.L.A.P.S. pattern, and myocardial transthyretin amyloid load in patients with newly confirmed transthyretin amyloid cardiomyopathy, or A.T.T.R.-C.M. The research aimed to clarify the histopathological and clinical implications of apical sparing in A.T.T.R.-C.M., a condition characterized by transthyretin amyloid deposition, left ventricular hypertrophy, and diastolic dysfunction. By establishing these associations, the study contributes to a more precise understanding of this complex disease and its prognostic indicators. Article 3: Survival Odds to Minimize Risk Heterogeneity Bias in Heart Failure Trials: Application to Dapagliflozin. Journal: Circulation. Heart failure PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41170566 Summary: This research established a novel methodological approach utilizing “survival odds” to minimize risk heterogeneity bias in heart failure clinical trials. The study addressed the issue where conventional Cox proportional hazards models can underestimate treatment effects due to a disproportionate reduction of event-free patients in control groups over time. By demonstrating the application of this survival odds methodology to dapagliflozin, the research offers a more robust framework for evaluating drug efficacy. This advance ultimately improves the accuracy of clinical trial outcomes for heart failure treatments. Article 4: Impact of the Swedish Care Coordination Act on Heart Failure Readmissions and Length of Stay. Journal: Circulation. Heart failure PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41170562 Su