Welcome to Cardiology Today – Recorded November 04, 2025. This episode summarizes 5 key cardiology studies on topics like s.P.A.P. and evolocumab. Key takeaway: Prognostic Markers for Recovered E.F. Heart Failure. Article Links: Article 1: Randomized Controlled Trial of Mechanical Thrombectomy With Anticoagulation Versus Anticoagulation Alone for Acute Intermediate-High Risk Pulmonary Embolism: Primary Outcomes from the STORM-PE Trial. (Circulation) Article 2: Prognostic Value of Exercise Right Ventricular-Pulmonary Arterial Coupling in Primary Mitral Regurgitation. (Circulation) Article 3: Efficacy and Safety of Very Low Achieved LDL-Cholesterol in Patients with Prior Ischemic Stroke. (Circulation) Article 4: Circulating Extracellular Vesicles in the Pathogenesis of Heart Failure in Patients with Chronic Kidney Disease. (Circulation) Article 5: Prognostic Value of Natriuretic Peptide Levels in Heart Failure With Recovered Ejection Fraction. (Circulation. Heart failure) Full episode page: https://podcast.explainheart.com/podcast/prognostic-markers-for-recovered-e-f-heart-failure-11-04-25/ Featured Articles Article 1: Randomized Controlled Trial of Mechanical Thrombectomy With Anticoagulation Versus Anticoagulation Alone for Acute Intermediate-High Risk Pulmonary Embolism: Primary Outcomes from the STORM-PE Trial. Journal: Circulation PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41183181 Summary: The S.T.O.R.M.-P.E. trial conducted the first reported randomized controlled trial to evaluate the efficacy and safety of mechanical thrombectomy, specifically computer assisted vacuum thrombectomy, combined with anticoagulation versus anticoagulation alone for acute intermediate-high risk pulmonary embolism. This trial focused on patients with an elevated right ventricular to left ventricular diameter ratio, who are at increased risk of early clinical decompensation and mortality. By rigorously comparing these treatment strategies, the study established foundational data on whether mechanical thrombectomy can effectively relieve acute right ventricular pressure overload and normalize hemodynamics to improve patient outcomes. Article 2: Prognostic Value of Exercise Right Ventricular-Pulmonary Arterial Coupling in Primary Mitral Regurgitation. Journal: Circulation PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41178584 Summary: This international multicenter cohort study aimed to evaluate the prognostic value of right ventricular-pulmonary arterial coupling in patients with primary mitral regurgitation. The study specifically assessed this coupling by measuring the ratio of tricuspid annular plane systolic excursion to systolic pulmonary artery pressure, both at rest and during exercise. By undertaking this comprehensive evaluation, the research established whether these non-invasive metrics provide a critical tool for risk stratification and improved management of patients with clinically significant primary mitral regurgitation. Article 3: Efficacy and Safety of Very Low Achieved LDL-Cholesterol in Patients with Prior Ischemic Stroke. Journal: Circulation PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41178569 Summary: This study investigated the efficacy and safety of achieving very low levels of low-density lipoproteins-cholesterol in patients with a history of ischemic stroke. Analyzing data from the F.O.U.R.I.E.R. trial, which studied evolocumab in stable atherosclerotic cardiovascular disease, researchers determined the impact of intensive L.D.L.-C reduction on recurrent stroke and other major adverse cardiovascular events. The findings provide crucial clarity on optimizing lipid management strategies for this high-risk patient population, aiming to improve secondary prevention outcomes following ischemic stroke. Article 4: Circulating Extracellular Vesicles in the Pathogenesis of Heart Failure in Patients with Chronic Kidney Disease. Journal: Circulation PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41178538 Summary: This cross-sec