Welcome to Cardiology Today – Recorded October 28, 2025. This episode summarizes 5 key cardiology studies on topics like PARTNER 3 trial and ESPRIT trial. Key takeaway: PREVENT Equations Refine Blood Pressure Control.. Article Links: Article 1: Transcatheter or Surgical Aortic-Valve Replacement in Low-Risk Patients at 7 Years. (The New England journal of medicine) Article 2: Using PREVENT Equations to Compare Intensive vs Standard Systolic Blood Pressure Control for Primary Prevention in SPRINT. (Journal of the American College of Cardiology) Article 3: Effect of Intensive Blood Pressure Control on Stroke: A Prespecified Secondary Analysis of the ESPRIT Trial. (Journal of the American College of Cardiology) Article 4: Clinical Practice of Surgical Treatment for Left-Sided Infective Endocarditis: Nationwide Data from the NIDUS Registry. (Circulation) Article 5: Long-Term Outcomes of Early Surgery Versus Conventional Treatment for Asymptomatic Severe Mitral Regurgitation: A Propensity Analysis. (Circulation) Full episode page: https://podcast.explainheart.com/podcast/prevent-equations-refine-blood-pressure-control-10-28-25/ Featured Articles Article 1: Transcatheter or Surgical Aortic-Valve Replacement in Low-Risk Patients at 7 Years. Journal: The New England journal of medicine PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41144631 Summary: This study from the PARTNER 3 trial aimed to provide longer-term clinical outcomes and valve durability assessments up to 7 years for low-risk patients with severe, symptomatic aortic stenosis. Patients were randomly assigned in a 1:1 ratio to undergo either transfemoral transcatheter aortic-valve replacement (T.A.V.R.) or surgical aortic-valve replacement. Prior 5-year data from this trial demonstrated similar outcomes between the two procedures. The research underscores the importance of continued long-term evaluation for valve durability and clinical effectiveness in these patients. Article 2: Using PREVENT Equations to Compare Intensive vs Standard Systolic Blood Pressure Control for Primary Prevention in SPRINT. Journal: Journal of the American College of Cardiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41125318 Summary: This secondary analysis of the SPRINT trial aimed to quantify the relative and absolute benefits and harms of intensive versus standard systolic blood pressure (S.B.P.) treatment using the new Predicting Risk of Cardiovascular Disease Events (PREVENT) equations. The PREVENT equations provide enhanced risk stratification by integrating estimated glomerular filtration rate, omitting race, and encompassing total cardiovascular disease events including heart failure. This research established a method for more precisely comparing intensive versus standard S.B.P. control by varying cardiovascular risk levels. The study demonstrates the utility of the PREVENT equations in refining primary prevention strategies for cardiovascular disease. Article 3: Effect of Intensive Blood Pressure Control on Stroke: A Prespecified Secondary Analysis of the ESPRIT Trial. Journal: Journal of the American College of Cardiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40864014 Summary: This prespecified secondary analysis of the ESPRIT trial evaluated the effects of intensive blood pressure control on stroke outcomes. Hypertensive patients with elevated cardiovascular risk were randomized to either intensive treatment, targeting systolic blood pressure (S.B.P.) below 120 millimeters of mercury, or standard treatment, aiming for S.B.P. below 140 millimeters of mercury. The study investigated the comparative impact of these two blood pressure management strategies on preventing stroke. This research highlights the critical role of S.B.P. reduction in stroke prevention, providing a focused comparison of intensive versus standard therapeutic approaches. Article 4: Clinical Practice of Surgical Treatment for Left-Sided Infective Endocarditis: Nationwide Data from the NIDUS Registry. Jour