Welcome to Cardiology Today – Recorded October 31, 2025. This episode summarizes 5 key cardiology studies on topics like dietary recommendations and diet. Key takeaway: Elevated Blood Pressure Tied to Dementia Risk.. Article Links: Article 1: Combined Adaptive Immune Mechanisms Mediate Cardiac Injury After COVID-19 Vaccination. (Circulation) Article 2: Genetic evaluation of early-onset atrial fibrillation: impact on patient management. (European heart journal) Article 3: Dementia risk across blood pressure categories: a South Korean nationwide study. (European heart journal) Article 4: Diet and Clinical Outcomes in a Heart Failure Population. (JACC. Heart failure) Article 5: Cardioimmunologic response patterns after an acute heart failure event: Design and first results of AHF-ImmunoCS. (ESC heart failure) Full episode page: https://podcast.explainheart.com/podcast/elevated-blood-pressure-tied-to-dementia-risk-10-31-25/ Featured Articles Article 1: Combined Adaptive Immune Mechanisms Mediate Cardiac Injury After COVID-19 Vaccination. Journal: Circulation PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41164857 Summary: This study investigated the previously elusive pathogenesis of acute myopericarditis (A.M.P.) developing after m.R.N.A. (messenger R.N.A.) COVID-19 vaccination. Researchers conducted in-depth phenotyping of peripheral blood T cells in patients who experienced acute myopericarditis post-vaccination. The findings definitively establish that combined adaptive immune mechanisms are responsible for mediating cardiac injury in these cases. This research provides critical understanding of this rare complication, strengthening the safety profile of m.R.N.A. vaccines by elucidating the biological mechanisms involved. Article 2: Genetic evaluation of early-onset atrial fibrillation: impact on patient management. Journal: European heart journal PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41166358 Summary: This study aimed to define the specific results and therapeutic impact of genetic evaluation for patients with early-onset atrial fibrillation (A.fib) referred to a dedicated precision medicine clinic. Patients diagnosed with atrial fibrillation before age 60 underwent a comprehensive assessment, including a three-generation pedigree, cardiac imaging, and ambulatory monitoring, in addition to standard evaluations. The research revealed that thorough genetic evaluation significantly impacts the management of early-onset atrial fibrillation, providing actionable information for personalized therapeutic strategies. This work underscores the value of precision medicine approaches for improving outcomes in specific atrial fibrillation populations. Article 3: Dementia risk across blood pressure categories: a South Korean nationwide study. Journal: European heart journal PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41165161 Summary: This nationwide Korean cohort study analyzed 2800000 adults aged 40 years or older to clarify dementia risk associated with the newly introduced ‘elevated blood pressure’ category from the 2024 European Society of Cardiology (E.S.C.) guidelines. Participants with prior dementia or related conditions were excluded to ensure robust analysis. The study successfully defined specific dementia risks across various blood pressure categories, including systolic blood pressure 120-139 m.m. H.g. or diastolic blood pressure 70-89 m.m. H.g. These findings provide crucial evidence for the clinical implications of the new E.S.C. classification, highlighting the importance of managing blood pressure for cognitive health even before it reaches hypertensive levels. Article 4: Diet and Clinical Outcomes in a Heart Failure Population. Journal: JACC. Heart failure PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41165628 Summary: This multinational substudy from the G-C.H.F. (Global Congestive Heart Failure) registry involved 3798 participants across 25 countries to investigate the associations between specific