Welcome to Cardiology Today – Recorded October 30, 2025. This episode summarizes 5 key cardiology studies on topics like nitric oxide and Familial hypercholesterolemia. Key takeaway: Early F.H. Diagnosis Via Newborn Blood Spots. Article Links: Article 1: Immediate or Deferred Nonculprit-Lesion PCI in Myocardial Infarction. (The New England journal of medicine) Article 2: PCI of Native Coronary Artery vs Saphenous Vein Graft After Prior Bypass Surgery: A Multicenter, Randomized Trial. (Journal of the American College of Cardiology) Article 3: Nuclear eNOS Interacts With and S-Nitrosates ADAR1 to Modulate Type I Interferon Signaling and Endothelial Function. (Circulation) Article 4: Geometric Features of Ventricular Tachycardia Corridors in Patients With Ischemic Cardiomyopathy. (Circulation) Article 5: Genetic Diagnosis of Familial Hypercholesterolemia in Residual Newborn Dried Blood Spots. (JAMA cardiology) Full episode page: https://podcast.explainheart.com/podcast/early-f-h-diagnosis-via-newborn-blood-spots-10-30-25/ Featured Articles Article 1: Immediate or Deferred Nonculprit-Lesion PCI in Myocardial Infarction. Journal: The New England journal of medicine PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41159879 Summary: This international, investigator-initiated, open-label, randomized controlled trial was designed to compare immediate percutaneous coronary intervention guided by instantaneous wave-free ratio with deferred percutaneous coronary intervention guided by cardiac stress magnetic resonance imaging. The study enrolled patients with S.T.-segment elevation myocardial infarction and multivessel disease. This research establishes a robust methodology to determine the optimal timing for treating nonculprit lesions in these high-risk patients. The findings from this trial will provide critical evidence to guide clinical practice for nonculprit-lesion management in S.T.-segment elevation myocardial infarction. Article 2: PCI of Native Coronary Artery vs Saphenous Vein Graft After Prior Bypass Surgery: A Multicenter, Randomized Trial. Journal: Journal of the American College of Cardiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41159978 Summary: The PROCTOR multicenter randomized trial was designed to compare clinical outcomes between percutaneous coronary intervention of the native coronary artery versus percutaneous coronary intervention of the saphenous vein graft. This study enrolled patients with prior coronary artery bypass grafting who presented with saphenous vein graft failure. This randomized comparison directly addresses a gap in current guidelines, which rely solely on observational data for recommendations regarding percutaneous coronary intervention strategy after bypass surgery. The findings will establish evidence-based guidance for optimal revascularization in this complex patient population. Article 3: Nuclear eNOS Interacts With and S-Nitrosates ADAR1 to Modulate Type I Interferon Signaling and Endothelial Function. Journal: Circulation PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41159282 Summary: This research assessed the role of nuclear endothelial nitric oxide synthase and nitric oxide signaling for endothelial cell function. Using loss-of-function approaches, confocal microscopy, and biochemical analyses, the study found that endothelial nitric oxide synthase localized in the endothelial cell nucleus generates nitric oxide. This nuclear endothelial nitric oxide synthase interacts with and S-nitrosates Adenosine Deaminase, R.N.A.-Specific, 1, consequently modulating type I interferon signaling. These findings reveal a novel molecular mechanism through which nuclear endothelial nitric oxide synthase regulates vascular inflammation and endothelial homeostasis, offering new therapeutic avenues for endothelial dysfunction. Article 4: Geometric Features of Ventricular Tachycardia Corridors in Patients With Ischemic Cardiomyopathy. Journal: Circulation PubMed Link: https://pubmed.ncbi.nlm.nih.gov/4