Welcome to Cardiology Today – Recorded October 29, 2025. This episode summarizes 5 key cardiology studies on topics like M.I.N.O.C.A. and multiomics. Key takeaway: A.E.D. Training Boosts Cardiac Arrest Survival.. Article Links: Article 1: Stratified treatment of myocardial infarction with non-obstructive coronary arteries: the PROMISE trial. (European heart journal) Article 2: Adaptation of right ventricular function following tricuspid transcatheter edge-to-edge repair. (ESC heart failure) Article 3: Improved Survival With Automated External Defibrillator-Only Training in a Public-Access Defibrillation Program: A 23-Year Database Analysis of Progetto Vita. (Journal of the American Heart Association) Article 4: A Multiomics Approach to Defining Target-Organ Injury in Youths With Primary Hypertension: The SHIP AHOY Cohort. (Journal of the American Heart Association) Article 5: GATA2 Mediates Macrophage Proliferation During Atherosclerosis. (Journal of the American Heart Association) Full episode page: https://podcast.explainheart.com/podcast/a-e-d-training-boosts-cardiac-arrest-survival-10-29-25/ Featured Articles Article 1: Stratified treatment of myocardial infarction with non-obstructive coronary arteries: the PROMISE trial. Journal: European heart journal PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41150941 Summary: The P.R.O.M.I.S.E. trial is a multicenter randomized study designed to evaluate the optimal management strategy for myocardial infarction with non-obstructive coronary arteries, or M.I.N.O.C.A. This condition is associated with significant mortality, rehospitalization, and angina burden, yet no prior randomized clinical trials had assessed its treatment. The trial’s objective is to determine if a stratified treatment approach improves clinical outcomes for M.I.N.O.C.A. patients compared to standard care. This research establishes a crucial framework to guide future clinical practice for this high-risk patient population. Article 2: Adaptation of right ventricular function following tricuspid transcatheter edge-to-edge repair. Journal: ESC heart failure PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41147662 Summary: This study characterized changes in right ventricular ejection fraction, or R.V.E.F., following tricuspid transcatheter edge-to-edge repair, or T-T.E.E.R. Patients with significant tricuspid regurgitation underwent T-T.E.E.R. and cardiac magnetic resonance, or C.M.R., imaging, with follow-up C.M.R. performed within one to three months. The research aimed to clarify the impact of T-T.E.E.R. on right ventricular remodeling and its prognostic implications. By classifying patients based on postprocedural R.V. data, this work provides a clearer understanding of right ventricular adaptation after T-T.E.E.R., which is vital for assessing patient outcomes. Article 3: Improved Survival With Automated External Defibrillator-Only Training in a Public-Access Defibrillation Program: A 23-Year Database Analysis of Progetto Vita. Journal: Journal of the American Heart Association PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41147502 Summary: This 23-year database analysis of the Progetto Vita, or P.V., program in Piacenza demonstrates improved survival for out-of-hospital cardiac arrest, or O.H.C.A., using automated external defibrillator, or A.E.D.,-only training. The P.V. project pioneered the first community-based A.E.D. program in Europe, and this extensive analysis provides critical survival data. The study highlights that early defibrillation is crucial for managing fatal arrhythmias, and A.E.D. use effectively minimizes time to defibrillation. This finding underscores the significant public health benefit of simplified A.E.D.-only training in public-access defibrillation programs for enhancing O.H.C.A. survival. Article 4: A Multiomics Approach to Defining Target-Organ Injury in Youths With Primary Hypertension: The SHIP AHOY Cohort. Journal: Journal of the American Heart Association PubMed Link: http