Welcome to ESC this year from Amsterdam, the city known of charming canals, cycling, and attractive architecture. There were 5 new guidelines, tens of session and 30 late-breaking clinical trials. In this episode, I've handpicked just seven trials. The choice was made based on the importance of the topics, the ability of the results to shake up the practice and challenge some cardiology dogmas. Some of the trials were positive, others were negative, but we learn in both cases. I'll be presenting the trials in ascending order of importance, saving the most impactful one for last. Here we go...