ISPOR—AS THE LEADING PROFESSIONAL SOCIETY IN HEALTH ECONOMICS AND OUTCOMES RESEARCH (HEOR)—continues to conduct horizon scanning and monitor the trends that affect healthcare decision making around the globe. This marks the fourth publication of the Society’s Top 10 HEOR Trends report that is now a biennial publication. The “2022-2023 ISPOR Top 10 HEOR Trends” report is based on input from its members and strategic curation from its Health Science Policy Council. The pandemic has disrupted virtually every aspect of our lives and so it is unsurprising that this publication of the trends report is heavily influenced by the impact of the COVID-19 pandemic. The pandemic permeates many of the trends and so warrants special treatment in this report. Real-world evidence (RWE) remains the number 1 trend for 2022-2023. The significance of RWE continues to grow, fueled by its importance in addressing the pandemic. Related, health data tie integrally to RWE and joins the trends list at number . Several new topics have arrived on the 2022-2023 trends list. Health equity comes to the top trends at number . While health disparities have always been an issue in healthcare, the pandemic has starkly illuminated these inequities and their devastating impact. Public health has joined the top trends at number ; also no doubt elevated by the impact of the pandemic. Health technology assessment (HTA) enters the list at number , and artificial intelligence joins the top trends at number.