As new drug discoveries advance, so should our ability to make sure those drugs will actually work. Yet pharmacokinetics still rely on non-human models, risking inefficient or even inaccurate development. Today, the path from concept to prescription can take years and well over $2 billion. But, drug development may become smarter thanks to organ-on-a-chip approaches — the specialty of Dr. Dan Tagle at the NIH. This month, Dr. Laura Moriarty and Dr. Tagle discuss the history and future possibilities of organs on chips to allow researchers to better mimic the human body.