In this episode of BioSpeak, we explore the three major types of RNA—mRNA, tRNA, and rRNA—and their coordinated roles in protein synthesis. We begin with messenger RNA (mRNA), which transmits genetic information from DNA to ribosomes as a template for protein assembly. Transfer RNA (tRNA) then delivers the necessary amino acids in response to mRNA codons, while ribosomal RNA (rRNA) forms a critical part of the ribosome, catalyzing peptide bond formation between amino acids. This episode also introduces the RNA-World hypothesis, suggesting RNA as a precursor to all life due to its ability to store genetic information and catalyze reactions. We conclude by discussing the evidence and open questions surrounding this hypothesis.