"James" reimagines the story of the escaped slave Jim, now named James Golightly, from his perspective as he seeks freedom and his family. Secretly literate, a skill acquired from Judge Thatcher's library, James escapes Miss Watson, fearing being sold down the river. He encounters Huckleberry Finn, and they journey down the Mississippi River, facing dangers and joining with con men.

James is sold to Henderson and endures harsh treatment at a sawmill before escaping with another slave, Sammy, who tragically dies. He travels with Norman, who sells him. Throughout his journey, James reflects on slavery and his desire to reunite with his wife Sadie and daughter Lizzie. He eventually leaves Huck and resolves to find his family in Edina, Missouri, even confronting Judge Thatcher again.

Driven by his determination, James gathers other slaves to join his quest. He faces accusations and reflects on the injustices of slavery, even resorting to violence against an overseer. His literacy is a source of strength. The journey highlights themes of survival, complex friendships, and the yearning for freedom and family. The novel is a work of fiction by Percival Everett.