Summary

The first source discusses the effectiveness of oral antiviral medications for Hepatitis B (HBV). While these medications are primarily thought to inhibit viral replication, recent studies show that they may also play a role in reducing the amount of viral DNA within the liver. This finding challenges the traditional view that these medications only prevent new infections. The second source provides evidence from a study that shows how tenofovir disoproxil fumarate (TDF), an antiviral medication, impacts the liver's immune microenvironment in HBV patients with mild liver damage. This study reveals that TDF treatment significantly reduces the amount of both integrated and non-integrated HBV DNA within the liver, suggesting that it may be more effective than previously thought. The third source highlights the characteristics of HBV integration in pediatric patients with chronic HBV infection. This study suggests that integration is more common in children compared to adults and may contribute to the accelerated loss of HBsAg in pediatric patients.

Sources:

https://gut.bmj.com/content/early/2024/10/08/gutjnl-2024-332526

Treat or Not to Treat - B肝治療與否 | #BTheVoice #B肝之聲 EP09 Lynette discovered she had hepatitis B during a health check-up at nursing school before her hospital internship. She was the only one in her family with the virus. Five years ago, she faced a dilemma about whether to start treatment, as her liver test results were normal. Ultimately, she decided to proceed with antiviral treatment. Lynette is grateful to her doctors for their support, especially as she was later diagnosed with breast and thyroid cancers. 故事簡介： Lynette 在醫院實習前的護理學校體檢中發現自己感染了B型肝炎。她是家中唯一感染B型肝炎的人。五年前，由於所有檢查結果都正常，她一直在掙扎是否應接受B肝治療。最終，她決定接受抗病毒藥物治療，並感謝醫生們在她B型肝炎和癌症治療過程中給予的支持。

一刀未剪 ～ 亞龍的B肝人生 | #B肝之聲 #BtheVoice

亞龍在專科學校健康檢查時發現B肝帶原，當初並未在意。當兵前體檢肝指數異常，但身體無異狀，因此仍未在意。 直到出社會開始工作，公司健康檢查發現肝發炎指數急速上升，食慾不振，且出現黃疸現象。住院幾週後又恢復正常。之後經過10年，肝臟持續輕度發炎，被診斷為肝硬化，且肝臟超音波影像出現陰影。現今他持續服用B肝抗病毒藥物，並成功減肥消除脂肪肝... 採訪者：楊淑貞 小姐 Unedited - Ya-Long's Life with Hepatitis B！ #BtheVoice

Stanly discovered he was a hepatitis B carrier during a health check-up at his technical school, but didn't pay much attention to it at the time. Before his military service, his medical examination showed abnormal liver indices, but since he had no symptoms, he still didn't take it seriously. It wasn't until he started working and a company health check revealed a rapid increase in liver inflammation indices, along with loss of appetite and jaundice. After a few weeks in the hospital, he returned to normal. Over the next ten years, his liver continued to have mild inflammation and he was diagnosed with cirrhosis, with shadows appearing in his liver ultrasound images. Now, he continues to take antiviral medication for hepatitis B and is actively losing weight to eliminate fatty liver. Host: Ms. Susan Yang

Jason contracted Hepatitis B and C due to a bone marrow transplant at a young age. Despite undergoing interferon treatment 12 years ago, he was unable to clear the viruses. Six years later, he successfully cured his hepatitis C using self-procured generic direct-acting antivirals (DAAs). To celebrate curing HCV, he went on a trip to Japan with his family, but fell ill upon arrival. He promptly returned to Taiwan and was hospitalized for acute exacerbation of chronic hepatitis B and was prepared for a liver transplantation... 澤民在年輕時因骨髓移植感染了B型和C型肝炎。儘管12年前接受了干擾素治療，他仍未能清除肝炎病毒。六年後，他通過自行購買的抗病毒學名藥物（DAA）成功治癒了C型肝炎。為了慶祝治癒C肝，他和家人一起去了日本旅行，但一到達就病倒了。他立刻返回台灣，因慢性B型肝炎急性惡化住院，並準備進行肝臟移植。

Jamie discovered she had Hepatitis B during her freshman health check-up in college. Both her maternal grandmother and her mother have chronic Hepatitis B. With her ongoing battle against Lupus and undergoing immunosuppressive therapy, she had begun antiviral therapy for Hepatitis B. Jamie urges young individuals to speak out about their infections to combat stigma and anticipates more effective treatments in the future. She emphasizes that treating Hepatitis B is less costly than treating liver cancer, pointing to the importance of starting treatment early before it progresses to liver cancer.

羅同學在大學新生健康檢查時發現自己感染了B型肝炎。她的外祖母和母親也都有慢性B型肝炎病毒感染。由於她還患有紅斑性狼瘡並接受免疫抑制治療，因此她已開始對B型肝炎進行抗病毒藥物治療。Jamie 鼓勵年輕人勇敢講出自己的感染情況，以對抗社會污名，並期待未來有更有效的治療方法。她表示，治療B型肝炎的費用比治療肝癌要低廉，所以不要等到得了肝癌才開始治療B肝。