Dr. Derrick DeSilva explains how mitochondrial dysfunction drives aging and disease, and why nutrients, lifestyle and toxin reduction matter. He describes cellular senescence, the drop in mitochondrial number and function with age, and the concept of mitochondrial biogenesis — rebuilding your cellular “engine.” Practical takeaways include exercise and muscle building, adequate protein and methylated B vitamins, and targeted supplements such as CoQ10, NAD/NADH, PQQ, alpha-lipoic acid and N‑acetylcysteine, along with stress management, reduced sugar, detox support and strong social connections to improve healthspan.