In this podcast, coauthors Simon D. Pouwels and Brady Rae discuss their recently published research article, "Interorgan Communication Between Lung and Colorectal Epithelial Cells Studied Using a Novel Multi-Organ-On-Chip System." The article describes development of a novel unidirectional millifluidic multi-organ-on-chip device to study the communication between human lung epithelial cells and colorectal cells following a toxic stimulus. Authors additionally discuss the versatility of the device to study communication across other cell types.     Interorgan Communication Between Lung and Colorectal Epithelial Cells Studied Using a Novel Multi-Organ-On-Chip System Brady Rae, Verena Bood, Hye-Jin Dijk, Gwenda F. Vasse, Barbro N. Melgert, Anika Nagelkerke, Janette K. Burgess, Dirk-Jan Slebos, Irene H. Heijink, Simon D. Pouwels Comprehensive Physiology 2025 15:5, e70051 https://doi.org/10.1002/cph4.70051