In this engaging episode of the AFSA Podcast, we are joined by Dr. Lawrence Hansen, a distinguished neuropathologist and advocate for animal-free research. We delve deep into the issues of animal experimentation in neuroscience research, addressing some of the ethical and scientific implications. The episode highlights how outdated methodologies persist despite advancements in human-relevant research techniques, emphasizing the need for a paradigm shift in scientific research practices. Dr. Hansen outlines the challenges inherent in studying neurodegenerative diseases such as Alzheimer’s with animal models, pointing out that these models fall short of replicating the human condition. He passionately argues for a shift towards human-based research applications that show promising advancements and efficacy over traditional animal testing methods. The discussion also uncovers systemic issues in scientific communities and funding bodies that sustain outdated practices, highlighting ethical concerns and potential pathways for advocacy and change. *Note: The first two questions include quite scientific explanations—but don’t worry, the conversation quickly opens up into broader ethical issues, so we encourage all listeners (even those without a science background) to stay tuned!For more info visit AFSA.  Click here to read more about primate experimentation in Australia.Read the transcript here.