Neuromuscular Blockade:
- Facilitates intubation
- Facilitates better surgical conditions
- Facilitates mechanical ventilation (i.e. ARDS, hyperventilating in increased ICP)
Two Categories:
- Depolarizing: ex. Succinylcholine (1-1.5mg/kg IV) depolarizes the muscle and prevents repolarization.
- Non-depolarizing: ex. Rocuronium (0.6-1.2mg/kg IV) Outcompetes ACh for the receptor on the endplate.
Big thanks to Suzanne George MD 2022 Candidate from the University of Calgary for editing the episode script!
References:
1. Butterworth J, Mackey D, Wasnick J. Morgan & Mikhail’s Clinical Anesthesiology. 5th ed. McGraw-Hill Education; 2013.
2. https://www.openanesthesia.org/aba_phase_ii_depolarizing_blockade/
3. Zhang Z, Guo Q, Wang E. Hyperventilation in neurological patients: from physiology to outcome evidence. Curr Opin Anaesthesiol. 2019;32(5):568-573. doi:10.1097/ACO.0000000000000764