In this episode, we head into the abdominal cavity—the metabolic engine room of the human body. From digestive organs and vascular highways to muscular walls and fascial compartments, the abdomen houses an intricate mix of systems. Our hosts dissect the layout, function, and clinical significance of this vital and variable region. Learning Objectives: Identify the major anatomical structures within the abdominal cavity Understand the layers of the abdominal wall and their surgical importance Recognize key surface landmarks and imaging strategies for the abdomen Explore conditions like hernias, appendicitis, and abdominal aortic aneurysm Clarify common anatomical confusions, including peritoneal vs. retroperitoneal spaces Gain insights into surgical approaches, visceral pain patterns, and diagnostic tools