In this episode, coauthors Gabriela Ribeiro, Marta P. Silvestre, Harriët Schellekens, and Cristina Cuesta-Marti discuss their recent review published in AJP-Gastrointestinal and Liver Physiology, titled "A menu for microbes: unraveling appetite regulation and weight dynamics through the microbiota-brain connection across the lifespan."   Appetite regulation is a complex and dynamic process influenced by behavioral, metabolic, and neurological factors — and increasingly, the gut microbiota. Our guests explore how the microbiota-gut-brain axis impacts appetite and obesity, highlighting how emerging omics tools and microbiota-targeted interventions may pave the way for precision treatments in nutrition and weight management. Tune in to hear how these researchers are bridging microbiology, neuroscience, and metabolism to better understand appetite across the lifespan.   A menu for microbes: unraveling appetite regulation and weight dynamics through the microbiota-brain connection across the lifespan Gabriela Ribeiro, Harriët Schellekens, Cristina Cuesta-Marti, Ivie Maneschy, Shámila Ismael, Amanda Cuevas-Sierra, J. Alfredo Martínez, Marta P. Silvestre, Cláudia Marques, André Moreira-Rosário, Ana Faria, Luis A. Moreno, and Conceição Calhau American Journal of Physiology-Gastrointestinal and Liver Physiology 2025 328:3, G206-G228