Dried Blood Spot: A Game Changer for HAE Diagnosis

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All Things Angioedema – Learning about angioedema with Dr. Thomas Buttgereit

ACARE, the Global Allergy and Asthma Excellence Network for Angioedema

43 episodes

1 week ago

Started by ACARE in 2023 within the ACARELevelUp program this podcast is an invaluable resource for health care professionals, and anyone interested in learning more about angioedema. Dr. Thomas Buttgereit, Head of the Study Center at Charité Berlin, discusses all forms of angioedema, their pathophysiology, burden and treatment strategies with experts from all over the world. All opinions expressed are those of the faculty. This content should not be taken as medical advice and is for informational purposes only. Learn more about ACARE here: https://acare-network.com/

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Dried Blood Spot: A Game Changer for HAE Diagnosis

All Things Angioedema – Learning about angioedema with Dr. Thomas Buttgereit

21 minutes 3 seconds

7 months ago

Dried Blood Spot: A Game Changer for HAE Diagnosis

In this episode, Thomas welcomes Dr. Jane Wong from Queen Mary Hospital, Hong Kong, to discuss a groundbreaking method for diagnosing hereditary angioedema (HAE) in regions with limited laboratory access. Traditional tests like complement C4, C1 inhibitor levels and C1 inhibitor function are crucial but not widely available in many parts of the world, delaying diagnosis and treatment.

They discuss:

🔹 What is dried blood spot (DBS) testing?

🔹 How does DBS compare to conventional lab tests?

🔹 Can DBS be used for large-scale screening and family testing?

🔹 What are the limitations and future applications of DBS?

Join us for an in-depth discussion on how this simple, cost-effective method can revolutionize HAE diagnosis and patient care worldwide.

Key Learnings from the Episode:

Traditional HAE testing (C4, C1 inhibitor levels and function) is limited in many regions, delaying diagnosis and treatment.

Dried blood spot (DBS) testing offers a reliable, cost-effective alternative, requiring only a few drops of blood.

DBS showed strong correlation with conventional lab results, making it a promising screening tool.

DBS allows for easy at-home or community-based sample collection, overcoming logistical barriers.

DBS can be used for family screening, identifying undiagnosed relatives in high-risk groups.

The method is stable and easy to transport, requiring minimal laboratory infrastructure.

More extensive studies are needed to validate DBS for broader population screening.

Future applications may include genetic testing for HAE with normal C1 inhibitor cases.

Chapters

00:00 Introduction to HAE and Diagnostic Challenges

03:12 Conventional Testing Methods for HAE

05:44 Exploring Alternative Diagnostic Methods

08:25 Validation of the Dried Blood Spot Method

10:40 Family Screening and Community Engagement

13:29 Limitations and Future Directions

16:07 The Future of HAE Diagnostics in Asia-Pacific

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