Even before the onset of the Covid-19 pandemic, preventive services, diagnostics, and treatments for pediatric HIV lagged far behind the comparable tools for adult populations. Recognizing that progress had stalled, in 2017 the Vatican convened leaders from pharmaceutical companies, regulatory agencies, research institutions, and community organizations to align interests and identify new areas for collaboration. This series of discussions gave rise to the Rome Action Plan, a rights-based partnership that has served as an accountability mechanism to generate higher-quality services for children living with HIV globally. In this episode of AIDS2021, Katherine E. Bliss speaks to Chip Lyons, President and CEO of the Elizabeth Glaser Pediatric AIDS Foundation; and Monsignor Robert Vitillo, Attaché at the Permanent Observer Mission of the Holy See to the UN in Geneva and Secretary General of the International Catholic Migration Commission to discuss the how the commitments made under the Rome Action Plan have advanced progress for children living with HIV and how that partnership model can be adapted for the Covid-19 crisis and used to drive innovation in the years to come.