This show will focus on the effect of stress on Crohn’s disease and ulcerative colitis. I will define stress as the feeling of being challenged by a threatening event or evolving situation. Everyone experiences some degree of stress in life, but when it becomes chronic and perceived as severe, it can have adverse health effects. Many patients attribute their initial diagnosis and subsequent flares to stressful life events. But does stress actually make the inflammation of inflammatory bowel disease worse? I review what the literature says and also present a case of a patient with Crohn's colitis who subsequently had a normal colonoscopy with normal biopsies after decreasing stress in his life. As a disclaimer, this is just an anecdote and does not constitute evidence. I am not recommending stress reduction as a primary treatment modality for IBD without adjunctive appropriate medical therapy. References: The Brain-Gut Axis and Stress in IBD by Bernstein: https://www.ncbi.nlm.nih.gov/pubmed/29173525 Manitoba Registry showing stress not associated with intestinal inflammation: https://www.ncbi.nlm.nih.gov/pubmed/26077178 UC patients with more inflammation with more stress: https://www.ncbi.nlm.nih.gov/pubmed/?term=10811330 Mindfulness Based Interventions in IBD by Hood et al : https://www.ncbi.nlm.nih.gov/pubmed/29173527 Wim Hof Method Paper: https://www.wimhofmethod.com/uploads/kcfinder/files/PNAS.pdf