"Accelerating Development" embarks on a comprehensive deep dive into Global Value Chains (GVCs), exploring their profound impact on global economies and development. We discuss how GVCs have historically fueled economic progress and poverty reduction, demonstrating a significantly more powerful effect on per capita income growth compared to traditional trade, driven by hyper-specialization and durable long-term relationships. However, the GVC landscape is actively evolving. We examine the slowing growth observed since the 2008 financial crisis, new technological advancements like 3D printing, and the increasing influence of geopolitical trade tensions, raising critical questions for researchers and policymakers on how developing countries can effectively navigate and benefit from these shifts. Our discussion highlights the key drivers for GVC participation, emphasizing the crucial role of factor endowments, market access, geographic connectivity, technology, foreign direct investment, and robust institutions. We also delve into the complexities of making GVCs work for broader, more inclusive, and sustainable development goals, addressing environmental impacts, potential social inequalities, and the vital importance of continuous upgrading and proactive risk management through smart policy. What new research questions emerge regarding the long-term path for countries deeply integrated into GVCs given these fundamental shifts?