In this episode of our Special Interviews Series with Institute Directors, we spoke to Dr Jean-Sébastien Silvestre, recently appointed Director of the Paris-Centre de Recherche Cardiovasculaire (PARCC, 2023-present). Dr Silvestre has a clear view of how to implement a successful research strategy at PARCC. He told us about the continuous dialogue with his team leaders, research technical staff and praised the work of the administration at the Institute. Dr Silvestre is constantly thinking about the future of PARCC, including how to recruit new talents and what kind of emerging technical innovation should be integrated in the tools that PARCC scientists have access to. He also described his own research interests that are focused on the inflammatory response and repair mechanisms after injury in the heart, telling us that the cardiovascular field attracted him from the very beginning of his scientific career and that led him to the position that he is now covering. Together with our previous interview with Dr Alain Tedgui, former PARCC founder and Director, we now have a comprehensive overview of the past and the future of this prestigious French institution. Listen on Apple Podcastshttps://podcasts.apple.com/us/podcast/about-enzymes-molecules/id1707039731Listen on Spotifyhttps://open.spotify.com/show/35yk70l7qLG9tHY6EjXFIh?si=7c6f9c51270543be#aboutenzymesandmolecules