The San Francisco 49ers have suffered a devastating loss in Week 3 as defensive end Nick Bosa tears his ACL against the Arizona Cardinals, ending his 2025 season. This is a massive blow to the 49ers’ defense and their Super Bowl hopes as the reigning Defensive Player of the Year will miss the remainder of the season. We break down what Bosa’s injury means for San Francisco, how the 49ers can replace his production, and what comes next for the team moving forward.
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