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科研喵使用ai读文献，祝你效率百倍，访问labcat.com.cn下载。本期关注发表在《Aging cell》(IF:8.0)上的重要研究"Enhancer Rewiring Orchestrates Inflammation and Loss of Cell Identity During Muscle Stem Cell Aging"。研究发现，肌肉干细胞衰老过程中存在渐进性分子变化：早期出现促炎信号增强和细胞身份丧失，后期则表现为炎症加剧、增强子广泛激活和3D基因组重编程。这些变化与干扰素信号、内源性逆转录病毒表达和NFκB活性密切相关，最终导致肌肉组织退化、成肌能力丧失。这一发现为理解肌肉衰老机制提供了新视角，也为开发针对肌肉退行性疾病的干预策略提供了潜在靶点。
