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本期关注发表在《Cancer letters》(IF:9.1)上的重要研究"KLF7 as a biomarker in the pre-metastatic state promotes colorectal liver metastasis via TGFβ autocrine signaling"。该研究首次确定了转移前状态(PMS)细胞的两个亚型，并发现KLF7是PMS1的关键生物标志物，通过激活TGFβ自分泌信号促进结直肠癌肝转移。更令人振奋的是，研究证实表没食子儿茶素没食子酸酯(EGCG)可抑制KLF7活性，为高表达KLF7的结直肠癌提供了新的治疗策略。这项突破性发现不仅深化了对转移机制的理解，更为临床干预提供了潜在靶点。
