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科研喵使用ai读文献,祝你效率百倍,访问labcat.com.cn下载。今天我们要关注的是发表在Nature structural & molecular biology(影响因子12.5)上的重要研究:"Mechanistic basis for protein conjugation in a diverged bacterial ubiquitination pathway."这项研究揭示了一种全新的细菌泛素化样途径(Bub),其包含功能性E1、E2和泛素样蛋白,但通过氧酯而非硫酯中间体发挥作用。研究团队发现Bub系统在抗噬菌体免疫中起作用,并可能参与应激条件下的翻译调控。这一发现不仅扩展了我们对蛋白质修饰机制的理解,也为开发新型抗菌策略提供了新思路。